SIC5-6, CAS [[2410846-16-9]]

Product Overview

• Article Name: SIC5-6, CAS [[2410846-16-9]]
• Biozol Catalog Number: FBM-10-4075
• Supplier Catalog Number: 10-4075
• Alternative Catalog Number: FBM-10-4075-10MG, FBM-10-4075-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3,3-(1-((4-Iodophenyl)sulfonyl)piperidine-4,4diyl)bis(1H-indole)

Product Description

Separase inhibitor

Product Properties

• Molecular Weight: 581.47
• Purity: 97% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [2410846-16-9]
• Formula: C27H24IN3O2S

Application Notes

• Application Notes: Separase is a cysteine protease that triggers chromosome segregation during mitosis and is highly overexpressed in many cancers. SIC5-6 is an inhibitor of separase with no inhibition of the related protease caspase-1 in vitro. HeLa cells with dysregulated separase activity showed severe chromosome segregation defects on treatment with 30 µM SIC5-6 indicating a potential attractive new chemotherapeutic target.