EVT0185, CAS [[2588489-03-4]]

Product Overview

• Article Name: EVT0185, CAS [[2588489-03-4]]
• Biozol Catalog Number: FBM-10-4113
• Supplier Catalog Number: 10-4113
• Alternative Catalog Number: FBM-10-4113-5MG, FBM-10-4113-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-[4-(5-Carboxy-5-methylhexyl)-phenyl]-2,2-dimethylhexanoic acid

Product Description

ATP citrate lyase inhibitor

Product Properties

• Molecular Weight: 362.51
• Purity: 98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [2588489-03-4]
• Formula: C22H34O4

Application Notes

• Application Notes: EVT0185 is an orally bioavailable ACLY (ATP citrate lyase) inhibitor (IC50 = 460 nM). It is converted to its active CoA thioester form in hepatocytes. Unlike bempedoic acid, EVT0185 inhibits AMPKß and also inhibits ACC1, ACC2, and ACSS2. It reduced tumor burden and synergized with lenvatinib, anti-PDL1, and VEGFR antibodies in multiple MASH-hepatocellular carcinoma mouse models. EVT0185 enhanced tumor immunogenicity via promotion of tumor-infiltrating B cells.