Chemical Name: (S)-N-(5-([1,1-Biphenyl]-4-carboxamido)-5-(1H-benzo[d]imidazol-2-yl)pentyl)-5-nitrofuran-2-carboxamide
STING antagonist
Molecular Weight:
537.58
Purity:
>98% by HPLC NMR (Conforms)
Form:
Off-white solid
Formula:
C30H27N5O5
Application Notes:
LB244 is a potent (EC50 = 800 nM THP1 cells) and irreversible STING antagonist with markedly enhanced proteome-wide selectivity compared to parent compound BB-Cl-amidine. Potently inhibits STING signaling in vitro in both mouse and human cells and in vivo when formulated in 20% DMSO.
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