Alpelisib, CAS [[1217486-61-7]]

Product Overview

• Article Name: Alpelisib, CAS [[1217486-61-7]]
• Biozol Catalog Number: FBM-10-4167
• Supplier Catalog Number: 10-4167
• Alternative Catalog Number: FBM-10-4167-5MG, FBM-10-4167-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (2S)-1-N-[4-Methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide. Alternate Names: NVP-BYL719, BYL719

Product Description

PI3K inhibitor

Product Properties

• Molecular Weight: 441.47
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1217486-61-7]
• Formula: C19H22F3N5O2S

Application Notes

• Application Notes: Alpelisib is a potent and selective (IC50s = 7.4 nM PI3Kalpha, 2.2 µM PI3Kß, 1.2 µM PI3KIdelta, 50-fold selectivity against 442 tested kinases) PI3Kalpha inhibitor.1 Approved for use in the treatment of HR(+), HER2(-), PIK3CA-mutated breast cancer. Alpelisib has been used in combination with various chemotherapeutics to treat ovarian2, colorectal3, kidney4, bladder5, and head and neck6 cancers.