Idasanutlin, CAS [[1229705-06-9]]

Product Overview

• Article Name: Idasanutlin, CAS [[1229705-06-9]]
• Biozol Catalog Number: FBM-10-4174
• Supplier Catalog Number: 10-4174
• Alternative Catalog Number: FBM-10-4174-5MG, FBM-10-4174-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid. Alternate Names: RG7388

Product Description

p53-MDM2 inhibitor

Product Properties

• Molecular Weight: 616.49
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1229705-06-9]
• Formula: C31H29Cl2F2N3O4

Application Notes

• Application Notes: Idasanutlin is a potent (IC50 = 6 nM) and selective inhibitor of MDM2, the primary negative regulator of p53.1 It blocks the p53-MDM2 interaction activating the p53 pathway leading to cell cycle arrest and apoptosis. Idasanutlin has displayed efficacy in the treatment of multiple cancers alone and in combination with other chemotherapeutics.2-6