SLC-0111, CAS [[178606-66-1]]

Product Overview

• Article Name: SLC-0111, CAS [[178606-66-1]]
• Biozol Catalog Number: FBM-10-4185
• Supplier Catalog Number: 10-4185
• Alternative Catalog Number: FBM-10-4185-5MG, FBM-10-4185-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-(4-Fluorophenyl)-3-(4-sulfamoylphenyl)urea. Alternate Names: U-104

Product Description

Carbonic anhydrase IX/XII inhibitor

Product Properties

• Molecular Weight: 309.32
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [178606-66-1]
• Formula: C13H12FN3O3S

Application Notes

• Application Notes: SLC-0111 is a potent inhibitor of carbonic anhydrases IX and XII (Ki = 45 nM IX, 4.5 nM XII)1. Active in multiple cancer models2-5 and has displayed synergism with conventional chemotherapy6. SLC-0111 upregulated CD8+ T cells in murine pancreatic cancer models7 and improved responses to immune checkpoint inhibitors8.