PITSTOP2, CAS [[1332879-52-3]]

Product Overview

• Article Name: PITSTOP2, CAS [[1332879-52-3]]
• Biozol Catalog Number: FBM-10-4195
• Supplier Catalog Number: 10-4195
• Alternative Catalog Number: FBM-10-4195-5MG, FBM-10-4195-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]naphthalene-1-sulfonamide

Product Description

Clathrin-mediated endocystosis inhibitor

Product Properties

• Molecular Weight: 473.36
• Purity: >98% by TLC NMR (Conforms)
• Form: Pink solid
• CAS Number: [1332879-52-3]
• Formula: C20H13BrN2O3S2

Application Notes

• Application Notes: PITSTOP2 inhibits clathrin-mediated endocytosis via blockade of endocytic ligand association with the clathrin terminal domain leading to clathrin coat assembly inhibition.1 It was able to cause a collapse of the nucleocytoplasmic permeability barrier and a reduction of Importin-ß binding.2 PITSTOP2 reduced viability in HeLa cells by trapping dividing cells in metaphase through loss of mitotic spindle integrity.3