RGN6024, CAS [[3055038-20-2]]

Product Overview

• Article Name: RGN6024, CAS [[3055038-20-2]]
• Biozol Catalog Number: FBM-10-4227
• Supplier Catalog Number: 10-4227
• Alternative Catalog Number: FBM-10-4227-5MG, FBM-10-4227-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-Methoxy-N-(5-((2-morpholinopyrimidin-5-yl)oxy)thiazol-2-yl)bicyclo[1.1.1]pentane-1-carboxamide

Product Description

Tubulin destabilizer

Product Properties

• Molecular Weight: 403.46
• Purity: >98% by HPLC NMR (Conforms)
• Form: Off-white to pale orange solid
• CAS Number: [3055038-20-2]
• Formula: C18H21N5O4S

Application Notes

• Application Notes: RGN6024 is an orally bioavailable and brain-penetrant tubulin destabilizer. It inhibits microtubule polymerization by binding to the colchicine binding site of ß-tubulin. Active in glioblastoma cell lines with nanomolar potency. RGN6024 was active in vivo in temozolomide-resistant LN-18 and BT142 glioblastoma xenograft models.