Chemical Name: (2S)-2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid
Glutamine transport inhibitor
Molecular Weight:
538.69
Purity:
98% by HPLC NMR (Conforms)
Form:
Off-white solid
CAS Number:
[1855871-76-9]
Formula:
C34H38N2O4
Application Notes:
Selective inhibitor of the alanine-serine-cysteine transporter 2 (ASCT2 or SLC1A5, IC50 = 9.0 µM rat and 9.6 µM human).1,2 It inhibited the uptake of both glutamine and possibly other amino acids in human cancer cells and reduced in vitro viability by at least 20% in more than half of 29 cancer cell lines screened.2 V-9302 decreased mTOR activity, elevated autophagy, and increased oxidative stress in multiple animal cancer models.2-5
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