ERGi-USU, CAS [[1147-56-4]]

Product Overview

• Article Name: ERGi-USU, CAS [[1147-56-4]]
• Biozol Catalog Number: FBM-10-4290
• Supplier Catalog Number: 10-4290
• Alternative Catalog Number: FBM-10-4290-10MG,FBM-10-4290-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: NSC139021

Product Description

ERG inhibitor

Product Properties

• Molecular Weight: 255.30
• Purity: 98% by TLC NMR (Confirms)
• Form: Red or Orange solid
• CAS Number: [1147-56-4]
• Formula: C13H9N3OS

Application Notes

• Application Notes: ERGi-USU selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.