Chemical Name: 3-((8-Amino-1,7-naphthyridin-5-yl)ethynyl)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
HUNK inhibitor
Molecular Weight:
544.58
Purity:
>98% by HPLC NMR (Conforms)
Form:
Yellow solid
Formula:
C30H27F3N6O
Application Notes:
HSL119 is an inhibitor of the hormonally upregulated neu-associated kinase (HUNK), IC50 = 1.7 µM. It inhibits several other kinases including ABL1, BRAF, FLT3, and RET. HSL119 displays antitumor activity in several HER2/neu+ breast cancer models.
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