Bedaquiline, CAS [[843663-66-1]]

Product Overview

• Article Name: Bedaquiline, CAS [[843663-66-1]]
• Biozol Catalog Number: FBM-10-4403
• Supplier Catalog Number: 10-4403
• Alternative Catalog Number: FBM-10-4403-5MG, FBM-10-4403-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol. Alternate Names: TMC207, R207910

Product Description

Antituberculosis / SARS-CoV2 3CLpro inhibitor

Product Properties

• Molecular Weight: 555.50
• Purity: 99% by HPLC, NMR (Conforms)
• Form: White solid
• CAS Number: [843663-66-1]
• Formula: C32H31BrN2O2

Application Notes

• Application Notes: Bedaquiline is a clinically useful antituberculosis agent that is active (MICs 0.030 to 0.120 µg/mL) against multi-drug resistant strains.1 It interferes with mycobacterial energy metabolism via binding to the oligomeric subunit c (AtpE)2 and subunit 3 of ATP synthase inhibiting ATP production.4 Bedaquiline has recently been found to be an inhibitor (IC50 = 18.7 µM) of the SARS-CoV-2 main protease, 3CLpro.5