XL413HCl, CAS [[2062200-97-7]]

Product Overview

• Article Name: XL413HCl, CAS [[2062200-97-7]]
• Biozol Catalog Number: FBM-10-4414
• Supplier Catalog Number: 10-4414
• Alternative Catalog Number: FBM-10-4414-5MG, FBM-10-4414-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 8-Chloro-2-[(2S)-pyrrolidin-2-yl]-3H-[1]benzofuro[3,2-d]pyrimidin-4-one hydrochloride

Product Description

Cdc7 inhibitor/CRISPR enhancer

Product Properties

• Molecular Weight: 326.18
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [2062200-97-7]
• Formula: C14H12ClN3O2HCl

Application Notes

• Application Notes: XL413 is a potent (IC50 = 4.8 nM) ATP-competitive inhibitor of the important DNA replication initiation kinase Cdc7 (DDK).1 It increases the efficiency of homology directed DNA repair in CRISPR-Cas9 gene editing.2 XL413 acted synergistically with other chemotherapy agents in various cancer models.3-5