HPI-1, CAS [[599150-20-6]]

Product Overview

• Article Name: HPI-1, CAS [[599150-20-6]]
• Biozol Catalog Number: FBM-10-4522
• Supplier Catalog Number: 10-4522
• Alternative Catalog Number: FBM-10-4522-5MG, FBM-10-4522-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate

Product Description

Hedgehog pathway inhibitor

Product Properties

• Molecular Weight: 463.52 (anhydrous)
• Purity: >98% (TLC: 80% Ethyl acetate/hexanes, Rf = 0.37)
• Form: Yellow solid
• CAS Number: [599150-20-6]
• Formula: C27H29NO6xH20

Application Notes

• Application Notes: HPI-1 is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. Inhibits both endogenous and exogenous Gli1/Gli2 activity. IC50s range from 0.2 to 6 µM for various cell-based assays.