UNC1999, CAS [[1431612-23-5]]

Product Overview

• Article Name: UNC1999, CAS [[1431612-23-5]]
• Biozol Catalog Number: FBM-10-4542
• Supplier Catalog Number: 10-4542
• Alternative Catalog Number: FBM-10-4542-5MG, FBM-10-4542-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide

Product Description

Methyltransferase inhibitor

Product Properties

• Molecular Weight: 569.74
• Purity: 98% by HPLC, NMR (Conforms)
• Form: White solid
• CAS Number: [1431612-23-5]
• Formula: C33H43N7O2

Application Notes

• Application Notes: UNC1999 is an orally bioavailable, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50s = 45 nM and 2 nM respectively).1 Inhibition of EZH2 with UNC1999 enhanced the efficacy of gefitinib in suppressing the proliferation of colon cancer cells