gamma-L-Glutamyl-p-nitroanilide HCl, CAS [[67953-08-6]]
Biozol Catalog Number:
FBM-10-4568
Supplier Catalog Number:
10-4568
Alternative Catalog Number:
FBM-10-4568-100MG,FBM-10-4568-250MG
Manufacturer:
Focus Biomolecules
Category:
Biochemikalien
Alternative Names:
GPNA
L-glutamine uptake inhibitor and gamma-glutamyl transpeptidase substrate
Molecular Weight:
303.70
Purity:
98%
Form:
Off-white solid
CAS Number:
[67953-08-6]
Formula:
C11H13N3O5 HCl
Application Notes:
L-gamma-Glutamyl-p-nitroanilide (GPNA) is a substrate for gamma-glutamyl transpeptidase. GPNA is used for the determination of gamma-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake - solute-linked carrier family A1 member 5 (SLC1A5)2 Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3
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