Gimeracil, CAS [[103766-25-2]]

Product Overview

• Article Name: Gimeracil, CAS [[103766-25-2]]
• Biozol Catalog Number: FBM-10-4601
• Supplier Catalog Number: 10-4601
• Alternative Catalog Number: FBM-10-4601-25MG, FBM-10-4601-100MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 5-Chloro-4-hydroxypyridine-2(1H)-one

Product Description

Dihydropyrimidine dehydrogenase inhibitor

Product Properties

• Molecular Weight: 145.54
• Purity: 98% by HPLC, NMR (Conforms)
• Form: White solid
• CAS Number: [103766-25-2]
• Formula: C5H4ClNO2

Application Notes

• Application Notes: Gimeracil is a dihydropyrimidine dehydrogenase (DPD) inhibitor. DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU). Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2 Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3