PF-9366, CAS [[72882-78-1]]

Product Overview

• Article Name: PF-9366, CAS [[72882-78-1]]
• Biozol Catalog Number: FBM-10-4635
• Supplier Catalog Number: 10-4635
• Alternative Catalog Number: FBM-10-4635-5MG, FBM-10-4635-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-(7-Chloro-5-phenyl)-[1,2,4]triazolo[4,3-a]quinoline-1-yl)-N,N,dimethylethanamine

Product Description

Methionine adenosyltransferase 2A inhibitor

Product Properties

• Molecular Weight: 350.85
• Purity: 98% by TLC NMr (Conforms)
• Form: Beige solid
• CAS Number: [72882-78-1]
• Formula: C20H19ClN4

Application Notes

• Application Notes: PF-9366 is an allosteric inhibitor (IC50 = 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1 It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50s of 1.2 µM and 225 nM respectively.