NS 1619, CAS [[153587-01-0]]

Product Overview

• Article Name: NS 1619, CAS [[153587-01-0]]
• Biozol Catalog Number: FBM-10-4643
• Supplier Catalog Number: 10-4643
• Alternative Catalog Number: FBM-10-4643-5MG, FBM-10-4643-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-(2-Hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole-2(3H)-one

Product Description

Selective KCa1.1 activator

Product Properties

• Molecular Weight: 362.23
• Purity: 98% by TLC NMR (Conforms)
• Form: White solid
• CAS Number: [153587-01-0]
• Formula: C15H8F6N2O2

Application Notes

• Application Notes: NS 1619 is a selective activator of large conductance Ca(2+)-dependent potassium channels (BKCa or KCa1.1).1,2 It was able to increase blood-brain tumor barrier permeability in rat brain tumor models.3,4 NS 1619 inhibited proliferation and induced apoptosis in A2780 ovarian cancer cells.5 Displays cardioprotective effects in an ischemia-reperfusion model6 and neuroprotective effects in a traumatic brain injury model7.