VU0810464, CAS [[2126040-21-7]]

Product Overview

• Article Name: VU0810464, CAS [[2126040-21-7]]
• Biozol Catalog Number: FBM-10-4662
• Supplier Catalog Number: 10-4662
• Alternative Catalog Number: FBM-10-4662-5MG, FBM-10-4662-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-(3-Chloro-4-fluorophenyl)-N-(2-cyclohexyl-5-methylpyrazol-3-yl)acetamide

Product Description

Kir3 activator

Product Properties

• Molecular Weight: 349.83
• Purity: >98% by TLC (NMR Conforms)
• Form: White solid
• CAS Number: [2126040-21-7]
• Formula: C18H21ClFN3O

Application Notes

• Application Notes: VU0810464 is potent (Kir3.1/3.2, GIRK1/2 EC50 = 165 nM) activator of G protein-gated inwardly-rectifying potassium channels (Kir3, GIRK).1,2 Displays selectivity for Kir3.1/3.2 versus Kir3.1/3.4 as well as selectivity for neuronal versus cardiac Kir3 channels. VU0810464 reduced stress-induced hyperthermia but not anxiety-related behavior in mice.