Chemical Name: 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
Mitochondrial pyruvate transporter inhibitor
Molecular Weight:
288.30
Purity:
98% by TLC NMR (Conforms)
Form:
Yellow solid
CAS Number:
[56396-35-1]
Formula:
C18H12N2O2
Application Notes:
Potent inhibitor of the mitochondrial pyruvate carrier (MPC).1 Rapidly increases glucose uptake in human monocytes.2 Attenuates mitochondrial oxidative phosphorylation and increases glycolysis creating greater stem-like properties in LnCap prostate cancer cells.3 Blocks the neuroprotective action of L-lactate or pyruvate during glutamate-induced excitotoxicity.4 Inhibits pyruvate transport across the plasma membrane of trypanosomes (Ki=49 µM).5
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