Necrosulfonamide, CAS [[1360614-48-7]]

Product Overview

• Article Name: Necrosulfonamide, CAS [[1360614-48-7]]
• Biozol Catalog Number: FBM-10-4860
• Supplier Catalog Number: 10-4860
• Alternative Catalog Number: FBM-10-4860-5MG, FBM-10-4860-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide

Product Description

Necroptosis inhibitor / MLKL inhibitor

Product Properties

• Molecular Weight: 461.47
• Purity: 98% by HPLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [1360614-48-7]
• Formula: C18H15N5O6S2

Application Notes

• Application Notes: Specifically blocks necroptosis downstream of RIP3 activation by preventing MLKL-RIP3 interaction.1 Displays neuroprotective effects after ischemic brain injury.2 Prevents cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells.3 Binds to gasdermin D inhibiting pyroptosis and associated inflammatory cell death and sepsis.4 Rescues cells from TLR3 ligand-induced death.5