Tegaserod is a potent and selective partial agonist of the serotonin 5-HT4 receptor.1,2 Tegaserod is an inhibitor of the RNA m6A reader YTHDF1.3 It reduced the viability of patient-derived AML cells and prolonged survival in xenograft models. Tegaserod also suppressed tumor growth in various models via inhibition of sonic hedgehog signaling4, MEK1/25, peroxisome pathway6, and others7.
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