Chemical Name: (2E)-N-[(4-Ethoxyphenyl)methyl]-3-[3-(4-piperidinyl)phenyl]-2-propenamide
METTL16 degrader
Molecular Weight:
364.49
Purity:
>98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[2869880-75-9]
Formula:
C23H28N2O2
Application Notes:
METTL16 degrader 15a is an RNA methyltransferase methyltransferase like protein 16 (METTL16) degrader. It reduced METTL16 protein levels and modulated the PI3K/AKT pathway. 15a inhibited the proliferation of HepG2 cells and induced apoptosis in vitro. It also inhibited the growth of hepatocellular carcinoma xenografts in mice.
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