Chemical Name: N-[3-(1H-Benzimidazol-2-yl)phenyl]-4-[(3,4-dihydro-2(1H)-isoquinolinyl)sulfonyl]benzamide
OTUD3 inhibitor
Molecular Weight:
508.60
Purity:
>98% by HPLC (NMR Conforms)
Form:
White or off-white solid
CAS Number:
[441290-65-9]
Formula:
C29H24N4O3S
Application Notes:
OTUDin3 (441290-65-9) is a potent inhibitor of the deubiquitinase OTUD3, a member of the ovarian tumor proteases which plays a key role in tumorigenesis, neurodegeneration, metabolism, and immunity. It inhibited non-small cell lung cancer growth, migration, and invasion via enhancing the ubiquitination and degradation of the anti-apoptotic protein GRP78. OTUDin3 inhibited lung cancer growth in an H1299 mouse xenograft model.
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