Biotin-isoxazole, CAS [[1377605-22-5]]

Product Overview

• Article Name: Biotin-isoxazole, CAS [[1377605-22-5]]
• Biozol Catalog Number: FBM-10-5400
• Supplier Catalog Number: 10-5400
• Alternative Catalog Number: FBM-10-5400-1MG, FBM-10-5400-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-(5-(Thiophen-2-yl)isoxazole-3-carboxamido)hexyl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate. Alternate Names: B-isox

Product Description

Precipitates RNA Binding Proteins

Product Properties

• Molecular Weight: 520.66
• Purity: 98% by TLC nMR (Conforms)
• Form: Beige solid
• CAS Number: [1377605-22-5]
• Formula: C24H32N4O5S2

Application Notes

• Application Notes: Exposure of cell or tissue lysates to biotin-isoxazole precipitates hundreds of RNA-binding proteins with significant overlap to the constituents of RNA granules.1,2 In one study roughly 580 nuclear proteins were identified as being precipitated by B-Isox including TAF15, RNA polymerase II (largest subunit), numerous subunits of the mediator complex as well as a variety of enzymes involved in epigenetic modification of histones.3 SR domains were found to be the determinant that facilitates B-Isox precipitation.4 Also allows for the fractionation / isolation of SG-associated proteins and RNA precipitates.5