Lactoyl phenylalanine, CAS [[183241-73-8]]

Product Overview

• Article Name: Lactoyl phenylalanine, CAS [[183241-73-8]]
• Biozol Catalog Number: FBM-10-5713
• Supplier Catalog Number: 10-5713
• Alternative Catalog Number: FBM-10-5713-5MG, FBM-10-5713-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[(2S)-2-hydroxy-1-oxopropyl]-L-phenylalanine. Alternate Names: Lac-Phe, N-lactoyl-phenylalanine

Product Description

Anorexigenic circulating metabolite

Product Properties

• Molecular Weight: 237.26
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [183241-73-8]
• Formula: C12H15NO4

Application Notes

• Application Notes: Exercise is associated with transient suppression of appetite which previously has been attributed to induction of appetite-regulatory hormone such as GLP-11 or the increase in circulating metabolites including L-lactate2. A targeted metabolomics approach with blood samples from two independent human exercise studies resulted in the identification of N-lactoyl-phenylalanine (Lac-Phe, 183241-73-8) as a highly upregulated circulating metabolite following exercise.3 Lac-Phe was shown, using pharmacological and genetic methods, to be an exercise-inducible metabolite that suppresses feeding and obesity. A single injection of Lac-Phe was demonstrated to reduce food intake by ~50% in diet-induced obese mice. However, Lac-Phe is completely inactive when administered orally.4