PD-L1 antibody recognizes programmed death-ligand 1 (PD-L1) protein, also known as B7 homolog 1 (B7-H1) and cluster of differentiation 274 (CD274) protein. PD-L1 is found on various cancer cells and transduces immunosuppressive signals by binding to the programmed cell death protein 1 (PD-1) on effector T cells, thereby diminishing immune system attacks on malignant cells. Blocking the interaction between PD-L1 and PD-1 with PD-L1 antibodies is generating great clinical interest as a mode of immunotherapy against a number of cancers.
Clonality:
Polyclonal
Concentration:
0.97 mg/ml (Please refer to the vial label for the specific concentration.)
Molecular Weight:
33
Sensitivity:
This antibody is specific for human PDL1 protein, and it does not cross react with human PDL2 protein.,KO/KD validation is based on published data (PMID: 31905966 and 33608051).
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
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