Deletions of the genes encoding the integrin alphaVbeta8 (Itgav, Itgb8) have been shown to result in abnormal vascular development in the CNS, including prenatal and perinatal hemorrhage. Other work has indicated that a major function of this integrin in vivo is to promote TGFbeta activation.
95 % as determined by Tris-Bis PAGE, 95 % as determined by HPLC.
Target:
Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer
Application Notes:
Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Other Recombinant Protein
Recombinant Mouse Integrin alpha V beta 8 (ITGAV&,amp,ITGB8) Heterodimer Protein was determined by Tris-Bis PAGE under reducing conditions.
The purity of Mouse ITGAV&,ITGB8 is greater than 95% as determined by SEC-HPLC.
Immobilized Mouse ITGAV&,ITGB8, His Tag at 5µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC<,sub>,50<,/sub>, of 2.4µg/ml determined by ELISA.
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