AM 251 is a potent CB1 receptor inverse agonist, with an IC50 of 8 nM at CB1 and 306-fold selectivity over CB2 receptors. AM 251 is also a GPR55 agonist with an EC50 of 39 nM and a µ-opioid receptor antagonist with a Ki of 251 nM. AM251 displays anorectic, antidepressant-like and analgesic effects in animals. AM251 can attenuate or reverse the nociceptive - hyperalgesia and allodynia - behaviours induced by burn injury.
Molecular Weight:
555.24
Purity:
98% by TLC , NMR conforms
Form:
Off-white solid
CAS Number:
[183232-66-8]
Formula:
C22H21Cl2IN4O
Target:
µ Opioid receptors,Cannabinoid receptors
Application Notes:
ProductType: Small molecules
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