Tertiapin LQ

Product Overview

• Article Name: Tertiapin LQ
• Biozol Catalog Number: ISC-KC-030
• Supplier Catalog Number: KC-030
• Alternative Catalog Number: ISC-KC-030
• Manufacturer: Isca Biochemicals
• Category: Biochemikalien
• Alternative Names: TPNLQ, TLQ

Product Description

Tertiapin LQ is a selective blocker of Kir1.1 channels, obtained by modifying tertiapin, the toxin from the honey bee venom. Tertiapin LQ blocks Kir1 with high affinity (1.1 nM) and high selectivity (>250-fold) over many commonly studied Kir subtypes. Application of tertiapin LQ locally in the superficial layers of the cerebellar cortex in decerebrate ferrets suppresses normal performance of Purkinje cell pause responses to the conditional stimulus with no detectable effect on spontaneous firing.

Product Properties

• Molecular Weight: 2428.03
• NCBI: 2008
• Purity: >95% by hplc
• Form: Freeze dried solid
• Sequence: H-Ala-Leu-Cys*-Asn-Cys*-Asn-Arg-Ile-Ile-Ile-Pro-Leu-Gln-Cys*-Trp-Lys-Lys-Cys*-Gly-Lys-Lys-NH2, disulfide bridges between cysteines 3 - 14 and 5 - 18
• Formula: C106H179N33O24S4
• Target: Potassium channels

Application Notes

• Application Notes: ProductType: Peptides