Orexin A (human, rat, mouse), CAS [[205640-90-0]]

Product Overview

• Article Name: Orexin A (human, rat, mouse), CAS [[205640-90-0]]
• Biozol Catalog Number: ISC-OX-050
• Supplier Catalog Number: OX-050
• Alternative Catalog Number: ISC-OX-050
• Manufacturer: Isca Biochemicals
• Category: Biochemikalien
• Alternative Names: Hypocretin 1

Product Description

Orexin A (human, rat, mouse) is an endogenous agonist at orexin receptors with Ki values of 20 and 38 nM for OX1 and OX2 receptors respectively. Orexin A stimulates feeding following central administration and is involved in other hypothalamic functions, influencing wakefulness by affecting dopamine, norepinephrine, histamine and acetylcholine systems to stabilize sleep cycles. An absence of orexin A causes narcolepsy, and in animal models, it can alleviate cognitive deficits caused by loss of sleep.

Product Properties

• Molecular Weight: 3561.12
• NCBI: 1998
• Purity: >95% by hplc
• Form: Freeze dried solid
• Sequence: Glp-Pro-Leu-Pro-Asp-*Cys-*Cys-Arg-Gln-Lys-Thr-*Cys-Ser-*Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (*disulphide bridges between cysteines 6 and 12, and cysteines 7 and 14)
• CAS Number: [205640-90-0]
• Formula: C152H243N47O44S4
• Target: Orexin receptors

Application Notes

• Application Notes: ProductType: Peptides