CPI-455 hydrochloride is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 hydrochloride mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents[1].
Molecular Weight:
314.77
Purity:
99.95
CAS Number:
[2095432-28-1]
Formula:
C16H15ClN4O
Target:
Histone Demethylase
Application Notes:
Reference compound
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