D-alpha-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of D-alpha-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. D-alpha-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-alpha-Hydroxyglutaric acid disodium is a weak competitive antagonist of alpha-ketoglutarate (alpha-KG) and inhibits multiple alpha-KG-dependent dioxygenases with a Ki of 10.87 mM. D-alpha-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-alpha-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5].
Molecular Weight:
192.08
CAS Number:
[103404-90-6]
Formula:
C5H6Na2O5
Target:
ATP Synthase,Endogenous Metabolite,mTOR,Reactive Oxygen Species (ROS),Reference Standards
Application Notes:
MCE Product type: Reference Standards
* VAT and and shipping costs not included. Errors and price changes excepted