FG 7142 (ZK 39106, LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the alpha1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106, LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the alpha1 subunit (EC50= 137 nM). FG 7142 (ZK 39106, LSU-65) can increase tyrosine hydroxylation and cause upregulation of beta-adrenoceptors in mouse cerebral cortex[1].
Molecular Weight:
225.25
Purity:
99.43
CAS Number:
[78538-74-6]
Formula:
C13H11N3O
Target:
GABA Receptor
Application Notes:
MCE Product type: Reference compound1
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