QX-314 is a membrane-impermeable quaternary Lidocaine (HY-B0185) derivative with sensory-selective blocking effects. QX-314 inhibits acid-induced esophageal hypersensitivity. QX-314 enters jugular ganglion cells via TRPV1 channels, blocks NaV1.8 channels, and thereby inhibits esophageal sensory conduction. QX-314 can alleviate acid-induced esophageal inflammation. QX-314 can be used for the research on gastroesophageal reflux disease (GERD)[1].
Molecular Weight:
263.40
CAS Number:
[21306-56-9]
Formula:
C16H27N2O
Target:
Sodium Channel,TRP Channel
Application Notes:
MCE Product type: Reference compound1
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