CGP 12177 (()-CGP 12177) is a beta-Adrenergic receptor (beta-AR) ligand. CGP 12177 is a beta3-AR (Ki = 88 nM) agonist with beta1/beta2-AR (Ki = 0.9 nM for beta1, Ki = 4 nM for beta2) antagonist action. CGP 12177 exhibits partial agonist properties for alpha1-AR in rat pulmonary artery. CGP 12177 regulates the expression of ucp and leptin genes in NMRI mice adipose tissues. CGP 12177 can be used for cardiovascular and metabolic disease research[1][2][3][4].
Molecular Weight:
279.33
CAS Number:
[81047-99-6]
Formula:
C14H21N3O3
Target:
Adrenergic Receptor
Application Notes:
MCE Product type: Reference compound1
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