Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2[1][2].
Molecular Weight:
498.56
Purity:
99.85
CAS Number:
[1703793-34-3]
Formula:
C26H27FN10
Target:
c-Kit,PDGFR
Application Notes:
MCE Product type: Reference compound
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