Carmegliptin (hydrochloride), CAS [[813452-14-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-10289A
Supplier Catalog Number:
HY-10289A
Alternative Catalog Number:
MCE-HY-10289A-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
RO-4876904 (hydrochloride)
Carmegliptin (hydrochloride) is an orally active and potent DPP-IV inhibitor with a human DPP-IV IC50 of 6.8 nM. Carmegliptin (hydrochloride) binds to the S1 pocket of DPP-IV, blocks the degradation of GLP-1, potentiates endogenous GLP-1, increases plasma insulin levels, alleviates hyperglycemia, improves glucose tolerance. Carmegliptin (hydrochloride) acts as a substrate for human P-glycoprotein without inhibiting the transporter, shows low in vitro cell permeability. Carmegliptin (hydrochloride) can be used for the research of type 2 diabetes, non-insulin-dependent diabetes mellitus[1][2][3].
Molecular Weight:
450.37
CAS Number:
[813452-14-1]
Formula:
C20H30Cl2FN3O3
Target:
Dipeptidyl Peptidase,GLP Receptor,P-glycoprotein
Application Notes:
MCE Product type: Reference compound
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