PG01 is a potent CFTR Cl- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with Kd values of 0.22 µM, 0.45 µM and 1.94 µM, respectively. PG01 is also effective on deltaF508 (Ka of 0.3 µM). PG01 increases deltaF508-CFTR Cl- current after adding Forskolin[1][2].
Molecular Weight:
439.55
Purity:
98.04
CAS Number:
[853138-65-5]
Formula:
C28H29N3O2
Target:
CFTR
Application Notes:
MCE Product type: Reference compound1
* VAT and and shipping costs not included. Errors and price changes excepted
