Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORgammat inhibitor (Ki=3.5 nM, IC50=17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORalpha and RORbeta isotypes. Vimirogant hydrochloride inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant hydrochloride has the potential for autoimmune disorders research[1][2].
Purity:
98.39
CAS Number:
[1802678-42-7]
Formula:
C27H35F3N4O3S.xHCl
Target:
ROR
Application Notes:
MCE Product type: Reference compound
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