SC75741 is a broad and efficient NF-kappaB inhibitor with an IC50 of 200 nM for p65[1]. SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-kappaB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins[2].
Molecular Weight:
565.67
Purity:
99.51
CAS Number:
[913822-46-5]
Formula:
C29H23N7O2S2
Target:
Influenza Virus,NF-kappaB
Application Notes:
MCE Product type: Reference compound
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