Sotrastaurin (acetate), CAS [[908351-31-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-10540
Supplier Catalog Number:
HY-10540
Alternative Catalog Number:
MCE-HY-10540-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
AEB071 (acetate)
Sotrastaurin (AEB071) acetate is a selective, orally active PKC inhibitor. Sotrastaurin acetate inactivates NF-kappaB by inhibiting PKC alpha, beta, theta, gamma subtypes, thereby reducing the transcription levels of immune response-related genes. Sotrastaurin acetate effectively inhibits alloreactive T cell proliferation, conventional T cell activation, as well as the production of pro-inflammatory cytokines and B lymphocytes. Sotrastaurin acetate also maintains the functional and phenotypic stability of regulatory T cells, enhances Foxp3 expression and restores the balance of helper T lymphocytes. Sotrastaurin acetate can prolong the survival time of allografts, and alleviate inflammatory responses and myasthenic symptoms by reducing anti-AChR antibody levels. Sotrastaurin acetate is widely used in studies related to kidney transplantation, psoriasis and myasthenia gravis[1][2][3].
Molecular Weight:
498.53
CAS Number:
[908351-31-5]
Formula:
C27H26N6O4
Target:
NF-kappaB,PKC
Application Notes:
MCE Product type: Reference compound
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