GNE-490, CAS [[1033739-92-2]]

Product Overview

• Article Name: GNE-490, CAS [[1033739-92-2]]
• Biozol Catalog Number: MCE-HY-10812
• Supplier Catalog Number: HY-10812
• Alternative Catalog Number: MCE-HY-10812-25MG,MCE-HY-10812-1MG,MCE-HY-10812-5MG,MCE-HY-10812-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

GNE-490, a (thienopyrimidin-2-yl)aminopyrimidine, is a potent pan-PI3K inhibitor with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kalpha, PI3Kbeta, PI3Kdelta and PI3Kgamma, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50=750 nM). GNE-490 shows potent suppression efficacy profile against MCF7.1 breast cancer xenograft model[1].

Product Properties

• Molecular Weight: 386.47
• Purity: 96.29
• CAS Number: [1033739-92-2]
• Formula: C18H22N6O2S
• Target: mTOR,PI3K

Application Notes

• Application Notes: MCE Product type: Reference compound