NAB2 is a neuroprotectant that targets the small GTPase Rab1a. NAB2 selectively binds to the GDP-bound form of Rab1a and protects multiple cell types from alpha-synuclein toxicity by increasing Rab1a expression. Rab1a regulates ER-to-Golgi trafficking and mediates endosomal trafficking events of the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 stimulates ubiquitination of related proteins in a Nedd4-dependent manner and rescues alpha-synuclein-associated trafficking defects associated with early-onset Parkinsons disease[1][2][3].
Molecular Weight:
389.88
Purity:
99.69
CAS Number:
[1504588-00-4]
Formula:
C23H20ClN3O
Target:
alpha-synuclein
Application Notes:
MCE Product type: Reference compound1
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