CM037 is a highly selective and competitive ALDH1A1 inhibitor (IC50=4.6 µM). CM037 blocks the catalytic activity of ALDH1A1, thereby inhibiting the activation of the downstream HIF-1alpha/VEGF pathway. CM037 is mainly used to study the ALDH1A1-mediated regulation of cancer stem cells (CSCs) and angiogenesis, especially in breast cancer, showing the potential to inhibit tumor angiogenesis and stem cell characteristics[1][2].
Molecular Weight:
431.57
Purity:
99.55
CAS Number:
[896795-60-1]
Formula:
C21H25N3O3S2
Target:
Aldehyde Dehydrogenase (ALDH)
Application Notes:
MCE Product type: Reference compound1
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