PHA-665752 is a selective, ATP-competitive, and active-site inhibitor of the catalytic activity of c-Met kinase (Ki=4 nM, IC50=9 nM). PHA-665752 exhibits >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases. PHA-665752 induces apoptosis and cell cycle arrest, and exhibits cytoreductive antitumor activity[1][2].
Molecular Weight:
641.61
Purity:
98.74
CAS Number:
[477575-56-7]
Formula:
C32H34Cl2N4O4S
Target:
Apoptosis,Autophagy,c-Met/HGFR
Application Notes:
MCE Product type: Reference compound
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