R406 free base is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 free base reduces immune complex-mediated inflammation[1]. R406 free base also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)[2].
Molecular Weight:
470.45
Purity:
99.07
CAS Number:
[841290-80-0]
Formula:
C22H23FN6O5
Target:
Apoptosis,FLT3,Syk
Application Notes:
MCE Product type: Reference compound
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