Inotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IkappaBalpha phosphorylation and NFkappaB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFkappaB pathways[1].
Molecular Weight:
218.21
CAS Number:
[906366-79-8]
Formula:
C12H10O4
Target:
MMP,NF-kappaB
Application Notes:
MCE Product type: Natural Products
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