JH-XI-10-02 is a PROTAC connected by ligands for Cereblon and CDK. JH-XI-10-02 is a highly potent and selective PROTAC CDK8 degrader, with an IC50 of 159 nM. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19[1].
Molecular Weight:
920.14
Purity:
99.73
CAS Number:
[2209085-22-1]
Formula:
C53H69N5O9
Target:
CDK,PROTACs
Application Notes:
MCE Product type: Reference compound1
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